Poststroke Angiogenesis

Poststroke angiogenesis, con: dark side of angiogenesis.

A ngiogenesis, the regrowth of new blood vessels, occurs after stroke 1 and thus raises hopes that this regeneration is beneficial for patients with stroke. There is no doubt, that the restoration of blood supply, providing oxygen and nutrients to the ischemic brain tissue, is beneficial for stroke recovery. However, it is debated, whether angiogenesis truly contributes to improved recovery. Th...

Poststroke angiogenesis, pro: making the desert bloom.

A ngiogenesis, in which existing blood vessels give birth to new capillaries, is a widely conserved response to hypoxia, including ischemic hypoxia. Angiogenesis occurs in peri-infarct regions of human brain after stroke, as documented by histological and immunohistochemical studies of postmortem tissue. Among many questions that might be asked about angiogenesis and stroke, the most apposite i...

Poststroke angiogenesis: blood, bloom, or brood?

Positron emission tomography imaging of poststroke angiogenesis.

BACKGROUND AND PURPOSE Vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) play important roles during neurovascular repair after stroke. In this study, we imaged VEGFR expression with positron emission tomography (PET) to noninvasively analyze poststroke angiogenesis. METHODS Female Sprague-Dawley rats after distal middle cerebral artery occlusion surgery were subjected to ...

Poststroke Outcomes

1 Department of Neurology and Neurosurgery, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA 2Department of Health Science & Research, College of Health Professions, Medical University of South Carolina, Charleston, SC 29425, USA 3 Ralph H. Johnson VA Medical Center, Charleston, SC 29425, USA 4Department of Neuroscience, College of Medicine, Medical Universit...